Memorial Şişli Hospital
What are the Best Hospitals for Treating Crohn's Disease?
Based on Bookimed’s clinic ranking policy, the best hospitals for Crohn’s disease are those known for their expertise in inflammatory bowel diseases, offering advanced diagnostic tools and comprehensive care. These hospitals, ranked among the top Bookimed partner clinics, provide world-class treatment options.
- Memorial Şişli Hospital (Turkey):
- Largest multidisciplinary medical center in Istanbul, accredited by Joint Commission International (JCI).
- Specialties include oncology, bone marrow transplant, IVF, neurosurgery, weight loss surgery, and organ transplant.
- 90% success rate in organ transplants.
- Treats patients from 92 countries annually.
- Medical Center in Solingen (Germany):
- Recognized among the top clinics in Germany by Focus magazine.
- Offers a multidisciplinary approach, advanced endoscopic techniques, immunosuppressive therapies, and surgical options.
- Treats over 60,000 patients yearly.
- Centro Médico Teknon (Spain):
- Internationally recognized for advanced diagnostics and treatments, including in oncology, neurosurgery, and stem cell therapy.
- Multiple JCI accreditations and high-profile clientele, including celebrities and athletes.
- Offers a range of services from online consultations to complex surgeries, with a dedicated medical team for international patients.
When choosing a hospital, consider the treatment methods the clinic specializes in, its location, and patient reviews. Selecting a hospital with a multidisciplinary team ensures that you receive holistic care tailored to your specific needs.
What Are the Main Treatments for Crohn's Disease Currently Available?
Hospitals specializing in Crohn's disease treatment offer a variety of therapeutic options to manage the condition, ranging from medications to surgical interventions. Let's take a closer look at them:
-
Anti-inflammatory drugs. Aminosalicylates (5-ASAs) such as mesalamine are primarily used for mild to moderate disease to reduce inflammation. Corticosteroids, like prednisone, are effective for short-term control during acute flare-ups but are not recommended for long-term use due to potential side effects.
-
Immunomodulators (Immunosuppressants). Drugs like azathioprine and methotrexate help maintain remission by suppressing the immune system. They have a slower onset but are crucial for long-term disease management and can help reduce the need for steroids.
-
Biologic therapies. These therapies target specific immune pathways and have revolutionized the treatment of moderate to severe Crohn’s disease. Anti-TNF agents, such as infliximab (Remicade) and adalimumab (Humira), are commonly used for rapid control. Meanwhile, newer biologics, including ustekinumab (Stelara) and vedolizumab (Entyvio), help block the migration of immune cells to the gut. Biosimilars, such as Simlandi, offer similar efficacy at potentially lower costs.
-
Antibiotics. Ciprofloxacin and metronidazole are used to manage infections and complications like fistulas or abscesses. While they help address these issues, their direct anti-inflammatory effects are limited.
-
Surgery. Surgical interventions are necessary for complications such as strictures and fistulas, or for cases of Crohn’s disease that do not respond to medical therapy. While surgery can provide symptom relief, recurrence of the disease is a common occurrence.
-
Nutritional therapy. Enteral nutrition, particularly in pediatric patients, is highly effective and supports the management of mild to moderate Crohn’s disease. It has been shown to help induce remission, especially in children.
In summary, the treatment approach for Crohn’s disease continues to evolve, with a focus on biologics, immunosuppressants, and personalized care. Advances in therapy offer hope for improved outcomes, particularly in severe cases.
What are the New Crohn's Disease Treatments?
Stem cells for Crohn’s disease offer new hope, particularly Mesenchymal stem cells (MSCs), which help reduce inflammation and repair tissue. Wang et al. (2023) report that MSC therapy can induce remission in up to 70% of patients, with significant improvements in perianal fistulas, as supported by Cheng et al. (2019).
Also, new biologics like Risankizumab-rzaa (Skyrizi) and Ustekinumab-auub (Wezlana) target specific immune pathways, improving outcomes with fewer side effects. Biosimilars such as Adalimumab-afzb (Amjevita) and Infliximab-axxq (Avsola) offer more affordable alternatives.
While these treatments are promising, Wang et al. (2023) and Cheng et al. (2020) emphasize that further studies are needed to confirm their long-term safety and effectiveness. As also noted by the American Cancer Society, continued research is essential to validate these therapies' durability and overall impact on Crohn’s disease management.
How Much Does Crohn’s Disease Treatment Cost?
The cost of Crohn’s disease treatment varies from $7,000 to $15,000 per patient per year, depending on:
- the type of medication;
- hospital location;
- treatment plan.
Biologics like infliximab and adalimumab typically cost $1,500 to $5,000 per month in high-cost countries such as the U.S., while treatment in countries like Turkey and Spain can be as low as $1,100 per month. According to the NIDDK, biologics are effective but expensive.
In addition to medication, hospital stays for procedures like bowel resections range from $15,000 to $55,000, with additional costs for consultations, nutritional supplements, and infusion therapy (up to $50,000 annually).
Also, the NHS reports that costs vary based on disease severity and treatment complexity. Consider both treatment effectiveness and cost when selecting a medical center.
The table below compares the average monthly costs for key treatments across the USA, Turkey, and Mexico, helping you make an informed decision based on your needs.
|
Treatment Type |
Average Cost in the USA (in USD, per month) |
Average Cost in Turkey (in USD, per month) |
Average Cost in Mexico (in USD, per month) |
|
Biologics (e.g., infliximab, adalimumab) |
$1,500 - $5,000 |
$1,100 |
$1,500 |
|
Hospital Stays for Bowel Resections |
$15,000 - $55,000 |
$300-700 |
$5,000 - $20,000 |
|
Consultations, Nutritional Supplements, and Infusion Therapy |
$1,500 to $3,000 |
$500-1,500 |
$1,500-$2,500 |
What Factors Influence the Cost of Crohn’s Treatment?
The cost of Crohn's disease treatment is influenced by:
- Treatment Type. Biologics and anti-TNF therapies are the most expensive, accounting for 60-70% of costs, as reported by PubMed Central.
- Disease Severity. Severe disease or complications, such as surgeries, increase costs.
- Age. According to Healthline Media, patients over 65 face up to 46% higher costs.
- Insurance Coverage. Even with insurance, out-of-pocket Crohn’s treatment costs average $2,200 annually, as reported by Healthline Media.
- Monitoring. Regular monitoring may raise short-term costs but reduce long-term expenses.
- Medication Administration. Infusions, such as infliximab, are more expensive than self-injections, like adalimumab.
- Emerging Factors. Biosimilars may lower medication costs in the future.
In summary, medication, disease severity, age, insurance, and monitoring all affect the cost, with biologics being the main expense.
What are the Average Prices for Basic Crohn’s Disease Diagnostics and Treatment Methods Available Abroad?
This table compares the cost of diagnostic and treatment services at top medical centers in Turkey, Germany, and Spain. It includes procedures like colonoscopy and gallbladder resection, helping you understand pricing differences for these treatments:
| Clinic | Diagnostics | Diagnostics Price (USD) | Treatments | Treatment Price (USD) |
| Memorial Şişli Hospital, Turkey | Colonoscopy | $1,500 - $2,000 | Resection of the gallbladder | $7,500 - $9,000 |
| Gastroscopy with biopsy | $1,500 | |||
| MRI of one area | $500 - $1,000 | |||
| Ultrasound | $200 | |||
| Biopsy | $1,500 - $2,500 | |||
| Medical Center in Solingen, Germany | Colonoscopy | $1,000 | Resection of the gallbladder | $8,000 |
| Gastroscopy with biopsy | $1,300 | |||
| MRI of one area | $1,000 | |||
| Ultrasound | $350 - $600 | |||
| Biopsy | -- | |||
| Centro Médico Teknon, Spain | Colonoscopy | $1,800 - $2,500 | ||
| Gastroscopy with biopsy | $1,000 | |||
| MRI of one area | $800 - $1,000 | |||
| Ultrasound | $200 - $300 | |||
| Biopsy | $3,000 - $5,000 |
*The cost estimates provided are based on Bookimed’s research, global statistics, and current medical data. They are approximate and may vary depending on factors such as individual treatment plans, the chosen medical facility, and changes in healthcare pricing over time.
This table highlights the cost differences across countries, with Turkey offering more affordable options. Prices may vary depending on the clinic and specific treatment details, so it's essential to confirm with the facility beforehand.
How Long Does Crohn’s Disease Treatment Last?
Crohn’s disease treatment requires lifelong management as it is a chronic condition with no cure. According to Healthline, while remission is possible, patients often require long-term management with medications like biologics, immunosuppressants, and corticosteroids.
Treatment has two phases:
- induction (to control inflammation and induce remission);
- maintenance (to prevent flare-ups).
Approximately 43-45% of patients remain in remission for 10 years after diagnosis, but relapses may still occur. Regular monitoring is crucial for adjusting treatment and preventing recurrence.
Is Surgery Necessary for Crohn’s Disease Treatment?
Surgery for Crohn’s disease is considered when the condition is unresponsive to medications or when complications like intestinal strictures, fistulas, abscesses, or perforation arise.
Procedures like bowel resections or strictureplasties remove or repair damaged parts of the intestine.
According to the Crohn’s & Colitis Foundation, approximately 30% of patients require surgery within the first five years, and 70-90% will eventually undergo it.
While surgery can improve quality of life, it’s not curative, as the disease can recur. Early intervention is crucial to avoid more complex surgeries later. Despite surgery, ongoing management with medications and regular monitoring is necessary for long-term care.
What are the Risks of Untreated Crohn's Disease?
The latest reports by Healthline Media and Medical News Today show that untreated Crohn’s disease can lead to serious complications, including:
- Intestinal Risks. Strictures, fistulas, abscesses, and ulcers.
- Nutritional Deficiencies. Malabsorption of vitamins and minerals leads to anemia and osteoporosis.
- Increased Risk of Colorectal Cancer. Chronic inflammation raises the risk, particularly in the colon.
- Systemic Complications. Joint pain, skin disorders, eye inflammation, liver disease, and blood clots.
- Life-Threatening Risks. Severe infections, intestinal obstruction, bowel perforation, and toxic megacolon.
Untreated Crohn’s can also cause frequent symptoms like abdominal pain, diarrhea, and fatigue, affecting quality of life and posing risks for pregnant women.
In summary, untreated Crohn’s increases the risk of severe, potentially life-threatening complications, stressing the need for early treatment.
How Can I Find the Best Crohn’s Disease Doctor Abroad?
To find the best Crohn’s disease specialist abroad, consider:
- the hospital’s reputation;
- the doctor’s expertise in treating inflammatory bowel diseases;
- patient reviews.
Using a platform like Bookimed can help you compare the top Crohn’s disease best hospitals, offering personalized recommendations based on your needs, treatment preferences, and budget.
Can I Travel with Crohn’s Disease?
Yes, you can travel with Crohn’s disease, but it requires careful planning and coordination with your healthcare team to ensure a safe trip. Here are the key recommendations from Crohn’s & Colitis Australia and Crohn's & Colitis UK:
-
Consult your IBD team 6-8 weeks before travel to arrange necessary vaccinations, medications, and a flare-up plan;
-
Carry enough medicine, plus extra for delays;
-
Bring documentation for airport security;
-
Be cautious with food and water, especially in high-risk areas;
-
Make sure to have comprehensive travel insurance covering Crohn’s disease-related care;
-
Choose aisle seats for easy access and pack a travel kit with essential items, such as anti-diarrheal medication, wet wipes, and electrolyte supplements.
With proper preparation, many people with Crohn’s disease can travel successfully and comfortably.
Does Life Insurance Cover Crohn's Disease Expenses?
Yes, life insurance with Crohn’s disease is generally available, but there are important factors to consider based on the severity and control of your condition:
-
According to Crohn’s & Colitis UK, it’s essential to disclose your Crohn’s diagnosis when applying to avoid non-disclosure issues, which could lead to claim denial.
-
If your Crohn’s disease is well-controlled with mild symptoms and medication, you can often get life insurance at standard rates.
-
However, if your condition is more severe or has complications, insurers may offer coverage at higher premiums or with exclusions related to Crohn’s disease.
-
Policies such as term life insurance, critical illness cover, and income protection are available, but they may come with higher costs or exclusions.
-
Your application may also be delayed if you have recently been hospitalized or are awaiting surgery. Factors like the time since diagnosis, treatment regimen, and lifestyle habits will affect your coverage options.
Shopping around and consulting brokers specializing in chronic conditions can help you find affordable life insurance with Crohn’s disease, and a Bookimed consultant can assist you in navigating your options and finding the best coverage for your needs, all at no cost to you.
What is the Success Rate of Crohn’s Disease Treatment?
Success rates for Crohn’s disease treatment depend on the type of treatment, disease severity, and hospital expertise.
The Mayo Clinic reports that biologics, such as infliximab and adalimumab, help 30-40% of patients achieve remission.
The NIDDK states that biologics are effective for treating moderate to severe cases, while the Memorial Şişli Hospital (Turkey) has a 90% success rate in organ transplants, indicating strong care for Crohn’s.
However, the Crohn’s and Colitis Foundation reports that 70% of patients will need surgery, with 30% experiencing symptom recurrence within three years. It’s essential to discuss potential outcomes with your healthcare provider to ensure personalized care.
Are there any alternative treatments for Crohn’s disease?
In addition to conventional treatments, some patients explore alternative therapies, such as
- dietary changes;
- herbal remedies;
- probiotics.
According to the NIDDK, probiotics may restore gut balance, while the National Institutes of Health (NIH) reports that acupuncture may relieve pain.
The Mayo Clinic states that omega-3 fish oil can help reduce inflammation, although the evidence is mixed. The Crohn’s and Colitis Foundation also notes that herbal remedies, such as turmeric, have anti-inflammatory effects. The American Psychological Association recommends mindfulness techniques, such as yoga, to reduce stress-related flare-ups associated with Crohn’s disease.
Can I Live a Normal Life with Crohn’s Disease?
Yes, according to the National Institutes of Health (NIH), many people with Crohn’s disease can live a normal life with proper management. Key factors include:
- Disease Activity. Remission improves quality of life, while flare-ups worsen symptoms.
- Treatment Adherence. Consistent use of medications reduces symptoms and hospitalizations.
- Lifestyle Adjustments. A healthy diet, regular exercise, and effective stress management can help control symptoms.
- Psychological Support. Managing anxiety and depression enhances overall well-being.
With the right care, many patients lead active personal and professional lives.
What Are the Symptoms of Crohn's Disease?
Photo by Mayo Clinic.
Symptoms of Crohn’s disease vary depending on the affected area of the digestive tract and can range from mild to severe. Based on the reports provided by the Crohn's & Colitis Foundation and the National Health Service, common Crohn’s disease symptoms include
Gastrointestinal Symptoms:
- Persistent diarrhea (sometimes bloody);
- Abdominal pain and cramping;
- Rectal bleeding and frequent bowel movements;
- Constipation, mouth sores, nausea, and weight loss.
Systemic Symptoms:
- Fatigue, fever, and delayed growth in children.
Extra-intestinal Symptoms:
- Joint pain, skin rashes, eye inflammation, liver issues, and anemia.
These symptoms occur during flare-ups, with periods of remission in between. The severity of the symptoms varies by individual and the location of the disease.
References
- Mayo Clinic. "Stem Cell Therapy." URL: https://www.mayoclinic.org (date of access: 22.07.2025).
- American Cancer Society. "New Treatments for Crohn’s Disease." URL: https://www.cancer.org (date of access: 22.07.2025).
- Wiley Online Library. "Crohn's Disease." URL: https://onlinelibrary.wiley.com/doi/10.1111/codi.16830 (date of access: 22.07.2025).
- National Institute of Health. "Study on Crohn’s Disease." URL: https://pubmed.ncbi.nlm.nih.gov/12197839/ (date of access: 22.07.2025).
- Crohn's & Colitis UK. "Travelling with Crohn's or Colitis." URL: https://crohnsandcolitis.org.uk/info-support/information-about-crohns-and-colitis/all-information-about-crohns-and-colitis/living-with-crohns-or-colitis/travelling-with-crohns-or-colitis (date of access: 22.07.2025).